Efficacy of severe acute respiratory syndrome vaccine based on a nonhuman primate adenovirus in the presence of immunity against human adenovirus
Identifieur interne : 004459 ( Main/Exploration ); précédent : 004458; suivant : 004460Efficacy of severe acute respiratory syndrome vaccine based on a nonhuman primate adenovirus in the presence of immunity against human adenovirus
Auteurs : YAN ZHI [États-Unis] ; Joanita Figueredo [États-Unis] ; Gary P. Kobinger [États-Unis] ; Heather Hagan [États-Unis] ; Roberto Calcedo [États-Unis] ; James R. Miller [États-Unis] ; GUANGPING GAO [États-Unis] ; James M. Wilson [États-Unis]Source :
- Human gene therapy [ 1043-0342 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
Abstract
Replication-deficient human adenovirus type 5 (AdH5) vectors can induce strong transgene product-specific cellular and humoral responses. However, many adult humans have neutralizing antibodies (NAbs) against AdH5 as a result of natural infection with this virus. Therefore, a chimpanzee adenovirus C7 (AdC7) vector was developed to circumvent interference by preexisting immunity to AdH5. This study evaluated the impact of preexisting immunity to human adenovirus on the efficacy of adenovirus-based vaccines against the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). Efficacy was assessed after intramuscular injection of the vector into mice and was measured as the frequency of SARS-CoV-specific T cells and NAbs against SARS-CoV. Immunogenicity of the AdH5-based vaccine was significantly attenuated or completely abolished when the preexisting anti-AdH5 NAb titer was higher than 40. Because 27% of human serum samples from the United States tested so far have an anti-AdH5 NAb titer higher than 40, our results suggested that a significant percentage of humans with preexisting anti-AdH5 immunity would not be candidates for vaccination with an AdH5-based genetic vaccine. In contrast, preexisting anti-AdH5 NAbs have a minimal effect on the potency of the AdC7-based genetic vaccine. Taken together, our studies warrant the further development of AdC7 as a vaccine carrier for human trials.
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Miller</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Guangping Gao" sort="Guangping Gao" uniqKey="Guangping Gao" last="Guangping Gao">GUANGPING GAO</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M." last="Wilson">James M. Wilson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0306386</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0306386 INIST</idno><idno type="RBID">Pascal:06-0306386</idno><idno type="wicri:Area/PascalFrancis/Corpus">000488</idno><idno type="wicri:Area/PascalFrancis/Curation">000502</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000484</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000484</idno><idno type="wicri:doubleKey">1043-0342:2006:Yan Zhi:efficacy:of:severe</idno><idno type="wicri:Area/Main/Merge">004685</idno><idno type="wicri:Area/Main/Curation">004459</idno><idno type="wicri:Area/Main/Exploration">004459</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Efficacy of severe acute respiratory syndrome vaccine based on a nonhuman primate adenovirus in the presence of immunity against human adenovirus</title><author><name sortKey="Yan Zhi" sort="Yan Zhi" uniqKey="Yan Zhi" last="Yan Zhi">YAN ZHI</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Figueredo, Joanita" sort="Figueredo, Joanita" uniqKey="Figueredo J" first="Joanita" last="Figueredo">Joanita Figueredo</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kobinger, Gary P" sort="Kobinger, Gary P" uniqKey="Kobinger G" first="Gary P." last="Kobinger">Gary P. Kobinger</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hagan, Heather" sort="Hagan, Heather" uniqKey="Hagan H" first="Heather" last="Hagan">Heather Hagan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Calcedo, Roberto" sort="Calcedo, Roberto" uniqKey="Calcedo R" first="Roberto" last="Calcedo">Roberto Calcedo</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Miller, James R" sort="Miller, James R" uniqKey="Miller J" first="James R." last="Miller">James R. Miller</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Guangping Gao" sort="Guangping Gao" uniqKey="Guangping Gao" last="Guangping Gao">GUANGPING GAO</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M." last="Wilson">James M. Wilson</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine</s1><s2>Philadelphia, PA 19104</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Human gene therapy</title><title level="j" type="abbreviated">Hum. gene ther.</title><idno type="ISSN">1043-0342</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Human gene therapy</title><title level="j" type="abbreviated">Hum. gene ther.</title><idno type="ISSN">1043-0342</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term><term>Gene therapy</term><term>Human adenovirus</term><term>Immunity</term><term>Primates</term><term>Severe acute respiratory syndrome</term><term>Vaccine</term><term>Vector</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Vaccin</term><term>Primates</term><term>Adenoviridae</term><term>Thérapie génique</term><term>Vecteur</term><term>Immunité</term><term>Adénovirus humain</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Replication-deficient human adenovirus type 5 (AdH5) vectors can induce strong transgene product-specific cellular and humoral responses. However, many adult humans have neutralizing antibodies (NAbs) against AdH5 as a result of natural infection with this virus. Therefore, a chimpanzee adenovirus C7 (AdC7) vector was developed to circumvent interference by preexisting immunity to AdH5. This study evaluated the impact of preexisting immunity to human adenovirus on the efficacy of adenovirus-based vaccines against the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). Efficacy was assessed after intramuscular injection of the vector into mice and was measured as the frequency of SARS-CoV-specific T cells and NAbs against SARS-CoV. Immunogenicity of the AdH5-based vaccine was significantly attenuated or completely abolished when the preexisting anti-AdH5 NAb titer was higher than 40. Because 27% of human serum samples from the United States tested so far have an anti-AdH5 NAb titer higher than 40, our results suggested that a significant percentage of humans with preexisting anti-AdH5 immunity would not be candidates for vaccination with an AdH5-based genetic vaccine. In contrast, preexisting anti-AdH5 NAbs have a minimal effect on the potency of the AdC7-based genetic vaccine. Taken together, our studies warrant the further development of AdC7 as a vaccine carrier for human trials.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Yan Zhi" sort="Yan Zhi" uniqKey="Yan Zhi" last="Yan Zhi">YAN ZHI</name></region><name sortKey="Calcedo, Roberto" sort="Calcedo, Roberto" uniqKey="Calcedo R" first="Roberto" last="Calcedo">Roberto Calcedo</name><name sortKey="Figueredo, Joanita" sort="Figueredo, Joanita" uniqKey="Figueredo J" first="Joanita" last="Figueredo">Joanita Figueredo</name><name sortKey="Guangping Gao" sort="Guangping Gao" uniqKey="Guangping Gao" last="Guangping Gao">GUANGPING GAO</name><name sortKey="Hagan, Heather" sort="Hagan, Heather" uniqKey="Hagan H" first="Heather" last="Hagan">Heather Hagan</name><name sortKey="Kobinger, Gary P" sort="Kobinger, Gary P" uniqKey="Kobinger G" first="Gary P." last="Kobinger">Gary P. Kobinger</name><name sortKey="Miller, James R" sort="Miller, James R" uniqKey="Miller J" first="James R." last="Miller">James R. Miller</name><name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M." last="Wilson">James M. Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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